On the sample mean after a group sequential trial
نویسندگان
چکیده
منابع مشابه
Estimation After a Group Sequential Trial.
Group sequential trials are one important instance of studies for which the sample size is not fixed a priori but rather takes one of a finite set of pre-specified values, dependent on the observed data. Much work has been devoted to the inferential consequences of this design feature. Molenberghs et al (2012) and Milanzi et al (2012) reviewed and extended the existing literature, focusing on a...
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we extend the method of adaptive two-stage sequential sampling toinclude designs where there is more than one criteria is used indeciding on the allocation of additional sampling effort. thesecriteria, or conditions, can be a measure of the targetpopulation, or a measure of some related population. we developmurthy estimator for the design that is unbiased estimators fort...
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Sample size estimation is an essential step in the design of clinical trials. For normal data, the calculation is based on estimates of the mean and variance of the treatment effect. These estimates are often unreliable because they are based on smaller studies, possibly looking at a different population than the one of interest. If the true treatment effect is overestimated and/or the variance...
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ژورنال
عنوان ژورنال: Computational Statistics & Data Analysis
سال: 2018
ISSN: 0167-9473
DOI: 10.1016/j.csda.2018.03.016